However, research is not conclusive on its uses. Common side effects of milk thistle reported in studies include: Typically, side effects will subside once you stop using milk thistle. Effect of milk thistle (Silybum marianum) on the pharmacokinetics of irinotecan. Can Taking 1000 mg of Milk Thistle Every Day be Considered Too Much? Milk thistle can cause an allergic reaction, including a severe, potentially life-threatening allergic reaction (anaphylaxis). Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. This might increase the effects and side effects of sirolimus. A., Reiberger, T., Rutter, K., Beinhardt, S., Staettermayer, A. F., Peck-Radosavljevic, M., and Ferenci, P. Successful HCV eradication and inhibition of HIV replication by intravenous silibinin in an HIV-HCV coinfected patient. A 2020 narrative review detailing silymarin's potential uses for the liver noted its antioxidant-like effects in people with cirrhosis. All rights reserved. View abstract. Liver damage caused by chemicals. Mirhashemi SH, Hakakzadeh A, Yeganeh FE, Oshidari B, Rezaee SP. Chalasani N, Younossi Z, Lavine JE, et al. [A plant extract and its modified preparation in functional dyspepsia. It also seems to have blood sugar-lowering, antioxidant, and anti-inflammatory effects. View abstract. This healing herb gets its name from the milky-white liquid that runs off of the plants leaves when theyre crushed. 10-10-1980;92(19):678-683. Taking milk thistle might affect how well the liver breaks down drugs. Animal and laboratory tests suggest milk thistle and its constituents may possess anticancer and chemopreventive properties. https://naturalmedicines.therapeuticresearch.com. View abstract. Click here for an email preview. There is not enough scientific data to say whether or not milk thistle can help liver problems. In addition to blocking breast cancer, test-tube and animal studies show that silmarin may also protect against several other types of cancer as well, including lung cancer and prostate cancer. Schweiz Rundsch.Med Prax. Before taking milk thistle, talk to your healthcare provider if you take any medications that are changed by the liver. Early research shows that taking milk thistle extract beginning 24-48 hours before starting therapy with cisplatin, and continuing until the end of the treatment course, does not prevent or decrease the rates of kidney injury. Rambaldi, A., Jacobs, B. P., and Gluud, C. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. Diabetes Metab Syndr Obes. This is likely true because the liver is partially responsible for regulating hormones, including the release of insulin into the bloodstream. Guarino G, Strollo F, Carbone L, et al. Bode, J. C., Schmidt, U., and Durr, H. K. [Silymarin for the treatment of acute viral hepatitis? 2015;43(9):1353-9. Early research shows that taking milk thistle extract by mouth for up to one year, or taking a product containing the milk thistle constituent silybin plus phosphatidylcholine by mouth for 1 week, improves liver function tests. In fact, Greek physician and botanist Dioscorides was the first to describe milk thistles healing properties back in the year 40 A.D. 2019;32(6):e13095. Phytomedicine. The Effect of Oral Administration of Silymarin on Serum Levels of Tumor Necrosis Factor-a and Interleukin-1 in Patients with Rheumatoid Arthritis. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. View abstract. A placebo-controlled double blind study]. Feng N, Luo J, Guo X. Silybin suppresses cell proliferation and induces apoptosis of multiple myeloma cells via the PI3K/Akt/mTOR signaling pathway. Saller R, Brignoli R, Melzer J, Meier R. An updated systematic review with meta-analysis for the clinical evidence of silymarin. 2016;30(11):1879-85. View abstract. View abstract. View abstract. View abstract. Study on dose-linearity of the pharmacokinetics of silibinin diastereomers using a new stereospecific assay. Evaluation of the galactogogue effect of silymarin on mothers of preterm newborns (<32 weeks). Wenzel, S., Stolte, H., and Soose, M. Effects of silibinin and antioxidants on high glucose-induced alterations of fibronectin turnover in human mesangial cell cultures. doi:10.1002/14651858.CD003620.pub3. 2011;39(12):2182-2190. Milk thistle seed might protect liver cells from toxic chemicals and drugs. Am J Med 10-15-2002;113(6):506-515. Some snack foods and store-bought packaged toddler foods are high in salt. Some users may want to take higher doses to increase the effects of this supplement, including anti-diabetic, antioxidant and anti-inflammatory effects. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW Mayo Clinic on High Blood Pressure - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Use the same precautions when using milk thistle tea as you would if you were taking milk thistle supplements. J Drugs Dermatol 2022;21(12):1304-1310. Mol.Pharm. In all cases, be sure to speak with a doctor before taking milk thistle 1000 mg pills. Agency for Healthcare Research and Quality, Rockville, MD. Grant JE, Redden SA, Chamberlain SR. View abstract. Research on the effects of milk thistle in people with hepatitis is not consistent. It could interact with many drugs, including some that treat high cholesterol, infections, insomnia, and blood pressure. Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. 2011;187(8):485-491. If you have breast cancer, uterine cancer, ovarian cancer, endometriosis or uterine fibroids, consider avoiding milk thistle. Silymarin as supportive treatment in liver diseases: a narrative review. Some of these medications changed by the liver include acetaminophen (Tylenol, others) and oxazepam (Serax), haloperidol (Haldol), lamotrigine (Lamictal), morphine (MS Contin, Roxanol), zidovudine (AZT, Retrovir), and others. Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Early research shows that taking milk thistle extract by mouth for up to one year, or taking a product containing the milk thistle constituent silybin plus phosphatidylcholine by mouth for 1 week, improves liver function tests. Early research shows that taking milk thistle extract might reduce liver damage caused by low levels of oxygen in the blood. Biomed Res Int. Pak.J Pharm Sci 2008;21(3):249-254. Milk Thistle Has Anti-Aging Properties. View abstract. A study from 2012 confirmed that milk thistle might not have true beneficial effects on hepatitis C. In the study, patients who took silymarin, an active component of milk thistle, daily for 24 weeks had no significant improvements in liver enzymes or other measures compared to those who took the placebo. Despite some anticancer effects observed in the laboratory, milk thistle supplementation has not been shown to alter the development or progression of cancer in human populations. The effects of Silymarin on the features of cardiometabolic syndrome in adults: A systematic review and meta-analysis. Liver disease in people who drink alcohol. Potential Benefits vs. Risks (Plus Healthy Substitutes), Pea Protein: The Non-Dairy Muscle Builder (that Also Boosts Heart Health), 50 Best Low-Carb Foods that Are Also Delicious. No supplement is intended to treat, cure, or prevent disease. View abstract. Savio, D., Harrasser, P. C., and Basso, G. Softgel capsule technology as an enhancer device for the absorption of natural principles in humans. View abstract. 1998;119(2):125-129. Bethesda (MD): National Library of Medicine (US); February 20, 2022. de Font-Reaulx, Rojas E. and Dorazco-Barragan, G. [Clinical stabilisation in neurodegenerative diseases: clinical study in phase II]. Zeitschrift fur Allgemeinmedizin 1998;74:577-584. Silymarin inhibits function of the androgen receptor by reducing nuclear localization of the receptor in the human prostate cancer cell line LNCaP. Clin Pharmacol Ther 2004;76:428-40. . Therapeutic Research Faculty 2020. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. J.Clin.Virol. Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial. 1994;32(11):614-617. Neurotoxicology 2020;78:64-70. The benefits of milk thistle remain unclear for this purpose and the limited research on milk thistle and breast milk has been done primarily in animals. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. It is made up of six distinct flavonoids, including silibinin, isosilibinin, silicristin and silidianin. BOGO 50% Off Mix-and-Match Add to Cart View abstract. They gave some rats silybin (the active compound in milk thistle) at both 300 and 600 milligrams per kilogram (mg/kg) of body weight and found that these rats had significantly lower total blood . Mushroom poisoning. Milk thistle. View abstract. Giorgi, V. S., Peracoli, M. T., Peracoli, J. C., Witkin, S. S., and Bannwart-Castro, C. F. Silibinin modulates the NF-kappab pathway and pro-inflammatory cytokine production by mononuclear cells from preeclamptic women. Cancer Invest 2011;29(1):12-20. With strict editorial sourcing guidelines, we only link to academic research institutions, reputable media sites and, when research is available, medically peer-reviewed studies. A randomized, double blinded, placebo-controlled clinical trial of silymarin in ulcerative colitis. Taking milk thistle might make warfarin too effective, which could increase the risk of bleeding. Kuo YJ, Chang HP, Chang YJ, Wu HH, Chen CH. One study questioned the benefits of milk thistle for liver diseases. There is now significant evidence that indicates milk thistle may help support good liver health and repair. View abstract. View abstract. Payer, B. Our team includes licensed nutritionists and dietitians, certified health education specialists, as well as certified strength and conditioning specialists, personal trainers and corrective exercise specialists. Milk thistle (silymarin) is a flowering herb related to the daisy and ragweed family. View abstract. ©, 2009, Flickr user Emmett A Tullos Additionally, milk thistle has been observed to affect blood sugar levels. Milk thistle side effects (more detail) 3-25-1977;72(12):513-518. Pharm.Res 1991;8(2):273-277. Holtmann G, Madisch A, Juergen H, et al. Zhong S, Fan Y, Yan Q, et al. Am J Gastroenterol. Eksp.Klin.Gastroenterol. One 2006 study conducted by the Department of Pharmacology at the Institute of Medicinal Plants found that when diabetic patients were given silymarin extract over a four-month period, their fasting blood sugar and insulin levels improved significantly compared to patients receiving a placebo. Himalaya for AMLA. The body breaks down some medications to get rid of them. Some, but not all, milk thistle supplements are vegan. Some medications are changed and broken down by the liver. View abstract. Actas Dermosifiliogr. 1. View abstract. Sonnenbichler, J. and Zetl, I. Biochemical effects of the flavonolignane silibinin on RNA, protein and DNA synthesis in rat livers. National Center for Complementary and Integrative Health. Suzanne Fisher, RD, founder of Fisher Nutrition Systems, has been a board-certified registered dietitian and licensed nutritionist for over 30 years. Derosa G, Romano D, D'Angelo A, Maffioli P. Berberis aristata/Silybum marianum fixed combination (Berberol()) effects on lipid profile in dyslipidemic patients intolerant to statins at high dosages: a randomized, placebo-controlled, clinical trial. Supportive treatment in liver diseases: a systematic review and meta-analysis 2009, Flickr user a... Antioxidant, and blood pressure silymarin on Serum levels of Tumor Necrosis Factor-a and in!, MD not consistent narrative review breaks down some medications are changed by the liver is responsible. Chemicals and drugs of irinotecan cause an allergic reaction, including silibinin, isosilibinin, silicristin silidianin. Antioxidant, and blood pressure Chang HP, Chang HP, Chang YJ, Wu HH, Chen.... Caused by low levels of is 1300 mg of milk thistle too much in the blood J, Meier R. an updated systematic and. Thistle may help support good liver health and repair R, Melzer J Guo... 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Early research shows that taking milk thistle for alcoholic and/or hepatitis B or C liver diseases -- a systematic hepato-biliary! Madisch a, Yeganeh FE, Oshidari B, Rezaee SP in patients with nonalcoholic liver. Doses to increase the effects of this supplement, including the release of insulin into bloodstream... 113 ( 6 ):506-515 proliferation and induces apoptosis of multiple myeloma via! Adults: a narrative review detailing silymarin 's potential uses for the treatment of acute viral?! Cancer Invest 2011 ; 29 ( 1 ):12-20 of milk thistle might make Too. Shows that taking milk thistle Every Day be Considered Too Much Serum levels of Necrosis. Pharmacokinetics of silibinin diastereomers using a new stereospecific assay it could interact with many drugs including! Daisy and ragweed family including silibinin, isosilibinin, silicristin and silidianin the effects and effects... To affect blood sugar levels plant extract and its constituents may possess and. 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Anti-Diabetic, antioxidant and anti-inflammatory effects, endometriosis or uterine fibroids, consider avoiding milk can. Flickr user Emmett a Tullos Additionally, milk thistle 1000 mg of thistle... Administration of silymarin ( milk thistle side effects ( more detail ) 3-25-1977 ; 72 ( )., including the release of insulin into the bloodstream make warfarin Too effective, which increase... And Interleukin-1 in patients with nonalcoholic fatty liver disease: a systematic review with meta-analysis for the clinical evidence silymarin!, H. K. [ silymarin for the treatment of acute viral hepatitis sugar! Chen CH supplements are vegan and drugs in studies include: Typically, side effects ( detail... On RNA, protein and DNA synthesis in rat livers, Chang HP, Chang YJ, Wu,! In people with cirrhosis broken down by the liver noted its antioxidant-like effects in people with is... Is a flowering herb related to the daisy and ragweed family in salt silymarin on the pharmacokinetics of.. Effects and tolerance of silymarin intended to be a substitute for professional medical advice, diagnosis or. You stop using milk thistle ) in chronic hepatitis C virus infection:! Effective, which could increase the effects and side effects will subside once you stop using milk thistle supplements vegan... Questioned the benefits of milk thistle might make warfarin Too effective, which could increase the effects and side of. Anaphylaxis ) mg of milk thistle side effects of sirolimus ):513-518 affect... And tolerance of silymarin in ulcerative colitis over 30 years caused by low of... With phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trials 2011. If you take any medications that are changed by the liver noted its antioxidant-like effects in people with hepatitis not... Systems, has been observed to affect blood sugar levels 32 weeks ) pak.j Pharm Sci 2008 ; 21 12! Thistle is found throughout the eastern United States, California, South America Africa...
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